If you are searching for a relaxing, quiet vacation with five start hotels, swimming pools and great comfort, then definitely don't go to the Amazon. Although it is possible to stay in a highly luxurious resort where even some celebrities stay for an astronomical amount of money, I believe that the Amazon is not about comfort. It's about experiencing the raw nature.
This trip was one of those that I enjoyed the most even if it was an organized tour by a travel agency. People who travel to the Amazon are usually very down to Earth and easy going, not afraid to "get dirty", I met some cool friends there. And, it was one of the best adventures of my life.